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Beaumont Laboratory

Mucopolysaccharides Screen (MPS), Urine

Glycosaminoglycans, MPS Screen, Mucopolysaccharides, Urine Quantitative, MAYO: MPSSC, EPIC: LAB6108, SOFT: XAMUC

Specimen Collection Criteria

Collect: 3.0 mL random urine specimen in a screw-capped container (preferred) or other sterile urine container. An early morning (first void) specimen is preferred. (Min: 1.5 mL)

Critical frozen. Freeze specimen immediately after collection.

Physician Office/Drawsite Specimen Preparation

Critical frozen. Maintain frozen (-20°C/-4°F or below) prior to transport.

Preparation for Courier Transport

Transport: 3.0 mL random urine specimen, frozen (-20°C/-4°F or below). (Min: 1.5 mL)

Rejection Criteria

  • Specimens not collected and processed as indicated.

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): 365 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.

Laboratory

Sent to Mayo Medical Laboratories, Rochester, MN.

Performed

Monday - Friday.
Results available in 11-19 days.

Reference Range

By report.

Test Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS), Spectrophotometry.

Clinical Utility

Glycosamineoglycan (GAG), also known as mucopolysaccharides, are sulfated polysaccharides that contain repetitive disaccharide unites attached to a protein core.

Mucopolysaccharidoses (MPS) are disorders caused by defects of the lysosomal enzymes involved in the degradation of GAG. These defects cause the accumulation of partially degraded GAG, particularly in lysosomes of mesenchymal and parenchymal tissues and excessive secretion of these accumulated compounds in tissue.

An abnormally elevated excretion of GAG is characteristic of MPS.

Clinical Disease

The mucopolysaccharidoses are a group of disorders including Hurler/Scheie, Hunter, Sanfilippo, Morquio, Maroteaux-Lamy, and Sly asssociated with coarse features, short stature, skeletal abnormalities with or without corneal clouding, cardiac complications, hepatosplenomegaly, and mental retardation. There is widespread lysosomal storage of mucopolysaccharides and increased excretion of dermatan, heparin, keratin, and/or chondroitin sulfate - collectively designated as glycosaminglycans (GAG).

CPT Code

82542, 83864.

Test Codes

MAYO: MPSSC, EPIC: LAB6108, SOFT: XAMUC

Last Updated

08/24/2017

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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.