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Beaumont Laboratory

Voriconazole Level

MAYO: VORI, EPIC: LAB6350, SOFT: XVORC

Specimen Collection Criteria

Collect: One plain Red-top tube.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and freeze (-20°C/-4°F or below).

Preparation for Courier Transport

Transport: 2.0 mL serum, frozen (-20°C/-4°F or below). (Min: 0.6 mL)

Rejection Criteria

  • Specimens not collected and processed as indicated.

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 28 days
Refrigerated (2-8°C or 36-46°F): 28 days
Frozen (-20°C/-4°F or below): 28 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.

Laboratory

Sent to Mayo Medical Laboratories, Rochester, MN.

Performed

Monday - Friday.
Results available in 3-7 days.

Reference Range

By report.

Test Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).

Interpretation

Peak levels greater than 6 ug/mL (and especially greater than 10 ug/mL) have been associated with toxicity in several reports. Timing of peak levels is about 30 minutes after an IV does and 2 hours after an oral dose.

Trough levels less than 1 ug/mL have been associated with suboptimal response in several reports.

Clinical Utility

Voriconazole (VFEND) is an antifungal agent approved for the treatment of invasive aspergillosis and candidemia/candidiasis. Monitoring peak levels of voriconazole is suggested in individuals with reduced liver function, individuals with CYP2C19 polymorphisms associated with poor metabolic function, patients taking other medications that affect CYP2C19 activity and in patients experiencing potential toxicity.

Monitoring trough levels may be reasonable in patients who are not responding optimally or have drug interactions that may decrease voriconazole levels, or to ensure adequate oral absorption.

CPT Code

80299.

Test Codes

MAYO: VORI, EPIC: LAB6350, SOFT: XVORC

Last Updated

03/04/2016

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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.