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Beaumont Laboratory

Vitamin A, Serum (Retinol)

Retinols, MAYO: VITA, EPIC: LAB6178, SOFT: XVITA

Instructions

  • The patient must be fasting 12-14 hours prior to specimen collection (for infants, collect specimen just prior to next schedule feeding).
  • Patient should not consume alcohol or ingest vitamin supplements for 24 hours prior to specimen collection.

Specimen Collection Criteria

Collect: One plain Red-top tube.
Also acceptable: One Gold-top SST tube.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes and immediately centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: Centrifuged collection tube, refrigerated (2-8°C or 36-46°F). (Min: 0.25 mL)

Rejection Criteria

  • Specimens not collected and processed as indicated.

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 14 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 14 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.

Laboratory

Sent to Mayo Medical Laboratories, Rochester, MN.

Performed

Monday - Friday.
Results available in 3-6 days.

Reference Range

By report.

Test Methodology

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).

Interpretation

The World Health Organization recommendations supplementation when vitamin A levels fall below 20.0 mcg/dL.

Severe deficiency is indicated at levels less than 10.0 mcg/dL.

Vitamin A values greater than 120.0 mcg/dL suggest hypervitaminosis A and associated toxicity.

Vitamin A toxicity occurs when retinol exceeds the capacity of retinol binding protein (RBP). Individuals with compromised renal function can retain RBP and may, therefore, have moderate retinol elevations.

Decreased levels may be seen in dietary deficiency or fat malabsorption syndromes such as liver, GI or pancreatic diseases, cystic fibrosis, xerosis, chronic infections, pyrexia, protein malnutrition and zinc deficiency with associated decreased retinol-binding protein; night or infantile blindness and hypothyroidism.

Increased levels may be due to hypervitaminosis, toxicity, chronic kidney disease, glucocorticoids, oral contraceptives or idiopathic hypercalcemia in infants.

Clinical Utility

This assay aids in the assessment of vitamin A deficiency and elevated vitamin A levels.

CPT Code

84590.

Test Codes

MAYO: VITA, EPIC: LAB6178, SOFT: XVITA

Last Updated

04/13/2016

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.