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Beaumont Laboratory

Interleukin 2

IL2, IL-2, T-Cell Growth Factor, (TCGF), Thymocyte Stimulation Factor, (TSF), Thymocyte Mitogenesis Factor, (TMF), T-Cell Replacing Factor, (TRF), Killer Helper Factor, (KHF), Interleukin 2 by MAFD, Interleukin-2, ARUP #51588, Antrim #81210, EPIC: LAB7072, SOFT: XINT2

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube or Dark Green-top Lithium Heparin tube.

Critical frozen. Send specimens for processing immediately after collection.Separate samples must be submitted when multiple tests are ordered.

Physician Office/Drawsite Specimen Preparation

Critical frozen. Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma into a plastic transport tube and freeze (-20°C/-4°F or below) immediately.

Preparation for Courier Transport

Transport: 1.0 mL serum or plasma, frozen (-20°C/-4°F or below). (Min: 0.3 mL)

Rejection Criteria

  • Specimens not collected and processed as indicated.

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 30 minutes
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): 1 year

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Monday, Wednesday, Friday.
Results available in 2-5 days.

Reference Range

Less than 12 pg/mL.

Test Methodology

Quantitative Multiplex Bead Assay.

Interpretation

Interleukin 2 (IL-2) is a glycoprotein produced by activated T-cells that has a variety of immunologic functions, the most notable being the ability to promote the proliferation and maturation of activated T-cells. IL-2 has been known by various names, including T-Cell Growth Factor (TCGF), Thymocyte Stimulation Factor (TSF), Thymocyte Mitogenesis Factor (TMF), T-Cell Replacing Factor (TRF), and Killer Helper Factor (KHF).

This test uses a kit designated by the manufacturer as "for research use, not for clinical use." The performance characteristics of this test were validated by ARUP Laboratories, Inc. The U.S. Food and Drug Administration (FDA) has not approved this test. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. ARUP is authorized under Clinical Laboratory Improvement Amendments (CLIA) and by all states to perform high-complexity testing.

Clinical Utility

Decreased production of this cytokine has been associated with the following disease states: systemic lupus erythematosus (SLE), Hodgkin's disease, lepromatous leprosy and AIDS. The ability of IL-2 to stimulate killer cells and enhance their cytotoxicity has led to the combined usage of IL-2 and lymphocyte activated killer cells (LAK) for the treatment of certain cancers.

CPT Code

83520.

Test Codes

ARUP #51588, Antrim #81210, EPIC: LAB7072, SOFT: XINT2

Last Updated

03/11/2016

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.