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Beaumont Laboratory

Lipoprotein (a)

Lp(a), Antrim #31428, EPIC: LAB5793, SOFT: LIPOA

Specimen Collection Criteria

Collect: One Gold-top SST tube.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged collection tube within eight hours of collection.

Preparation for Courier Transport

Transport: Centrifuged collection tube, refrigerated (2-8 °C or 36-46 °F). (Min: 0.5 mL serum)

Rejection Criteria

  • Hemolyzed specimens.
  • Severely lipemic specimens.

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers® with Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers® without Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 1 month

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Special Testing Laboratory.

Performed

Monday, Wednesday, Friday.
Results available in 2 business days. 

Reference Range

Less than or equal to 30 mg/dL.

Test Methodology

Immunoturbidimetry.

Interpretation

  • Lp(a) is a lipoprotein which is very similar in structure to low density lipoprotein (LDL). The main difference between these two molecules is that Lp(a) contains an additional protein, apo(a). Lp(a) has been found to be pathogenic and its level is an independent risk factor for the development of coronary heart disease and stroke. Levels in the serum appear to be under fairly strict genetic control and seem to be difficult to manipulate by diet and traditional lipid-lowering drugs. Monosaturated fats and high intake of polyunsaturated fats may be useful in lowering Lp(a) levels.
  • As indicated Lp(a) levels are genetically influenced but can also vary considerably within a given population. Africans and African-Americans have higher levels than Caucasians.
  • Lp(a) levels are transiently reduced by about 20% after an acute myocardial infarction.
  • Growth hormone therapy and cyclosporine therapy for organ transplantation have been associated with increased Lp(a) levels.

Clinical Utility

Lp(a) measurement is useful in determining whether a patient is at increased risk of developing vascular disease. Quantitation of Lp(a) may be useful in patients with:

  • A history of premature coronary artery disease.
  • A family history of coronary artery disease.
  • A history of premature cerebrovascular disease.
  • A family history of cerebrovascular disease.

A level greater than 34 mg/dL has been associated with a 2 fold increased risk of developing atherosclerosis. Africans and African-Americans tend to have higher levels of Lp(a) than Caucasians.

CPT Code

83695.

Test Codes

Antrim #31428, EPIC: LAB5793, SOFT: LIPOA

Last Updated

11/29/2017

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.