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Beaumont Laboratory


Zoloft, ARUP #98745, EPIC: LAB6151, SOFT: XSERT

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Lavender-top EDTA tube.

Do not use Serum Separator Tubes.

Time of Collection: Trough, just prior to the next dose.

Physician Office/Drawsite Specimen Preparation

Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Min: 0.5 mL)

Rejection Criteria

  • Serum Separator (SST) tubes.
  • Specimens not collected and processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 5 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 6 months

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to ARUP Laboratories, Salt Lake City, UT.


Tuesday, Friday.
Results available in 2-6 days.

Reference Range

Therapeutic Range: Not well established.
Toxic Range: Greater than 300 ng/mL.

Test Methodology

Quantitative Liquid Chromatography/Tandem Mass Spectrometry.


No therapeutic range exists for sertraline. Dosing should begin at 50 mg/d, not to exceed 200 mg/d. Dosing above 200 mg/d is associated with increased adverse effects and decreased efficacy. Dosing of 50-200 mg/d gives serum values ranging from 30-200 ng/mL.

Clinical Utility

Sertraline is indicated for the treatment of depression. This assay is used for the therapeutic monitoring and toxicity assessment of sertraline.

CPT Code

80332, alt G0480.

Test Codes


Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.