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Beaumont Laboratory

Zinc Protoporphyrin (ZPP), Whole Blood

ARUP #20605, EPIC: LAB6189, SOFT: XZPP

Specimen Collection Criteria

Collect (preferred specimen): One Lavender-top EDTA tube.
Also acceptable: One Royal Blue-top EDTA tube.

Physician Office/Drawsite Specimen Preparation

Do not centrifuge or freeze. Maintain whole blood refrigerated (2-8°C or 36-46°F) prior to transport.

Preparation for Courier Transport

Transport: 1.0 mL whole blood, refrigerated (2-8°C or 36-46°F). (Min: 0.2 mL)

Rejection Criteria

  • Centrifuged specimens.
  • Frozen specimens.
  • Clotted specimens.
  • Hemolyzed specimens.
  • Specimens not collected and processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 30 hours
Refrigerated (2-8°C or 36-46°F): 5 weeks
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to ARUP Laboratories, Salt Lake City, UT.


Monday - Friday.
Results available in 2-5 days.

Reference Range

0-69 mcmol ZPP/mol heme.

Test Methodology

Quantitative Hematofluorometry.


By report.

A more specific test for free protoporhyrin is Total Serum Porphyrins. The erythrocyte protoporhyrins test, Free Erythrocyte Porphyrins (FEP), can also be considered.

Clinical Utility

Elevated ZPP results are seen in early (as well as late) iron deficiency, in the anemia of chronic disease, and in chronic lead poisoning (typically when blood lead is greater than 25 mcg/dL). Elevated protoporphyrin (as in erythropoietic protoporphyria) can also increase the ZPP signal. Causes for false elevations include markedly elevated bilirubin and riboflavin. Specimens which are hemolyzed, clotted, or improperly aliquoted can also show false elevations.

CPT Code


Test Codes

ARUP #20605, EPIC: LAB6189, SOFT: XZPP

Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.