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Beaumont Laboratory

Tricyclic Antidepressant (TCA) Screen, Urine

Elavil, Aventyl, Pamelor, Tofranil, Norpramin, Sinequan, Amitriptyline, Nortriptyline, Imipramine, Desipramine, Doxepin, EPIC: LAB7095, SOFT: TCASC

Specimen Collection Criteria

Collect: 30 mL random urine in a sterile collection container.

Physician Office/Drawsite Specimen Preparation

Maintain specimen refrigerated (2-8 oC or 36-46 oF) prior to transport.

Preparation for Courier Transport

Transport: Urine in a sterile collection container, refrigerated (2-8°C or 36-46°F). (Min: 15 mL urine)

Rejection Criteria

  • Specimens not collected and processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 8 hours
Frozen (-20°C/-4°F or below): 3 months

Specimen Storage in Department Prior to Disposal:

Frozen (-20°C/-4°F or below): 2 months


Royal Oak Toxicology Laboratory.


Sunday - Saturday, 24 hours a day.
STAT results available within 4 hours of receipt in the Laboratory.
Routine results available within 24 hours.

Reference Range


Test Methodology

Gas Liquid Chromatography/Mass Spectrometry. (GC/MS).

This test was developed and its performance characteristics determined by Beaumont Health. It has not been cleared or approved by the FDA. The Laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes and should not be regarded as investigational or for research.


This assay screens urine for the presence of the following drugs: Amitriptyline, NortriptylineImipramine, Desipramine, Doxepin, Clomipramine, Trimipramine and metabolites.

Serum quantitation of these drugs is available as a separate request.

Clinical Utility

This assay is designed primarily for the detection of toxic concentrations of tricyclic antidepressants.

CPT Code


Test Codes


Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.