800-551-0488

Lab results are too important to go anywhere else

Beaumont Laboratory

Insulin Like Growth Factor Binding Protein 3

IGF Binding Protein 3, IGFBP3, EPIC: LAB7118, SOFT: IGFP3

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged collection tube within eight hours of collection. (Minimum Serum: 0.5 mL)

Preparation for Courier Transport

Transport: Centrifuged collection tube, refrigerated (2-8°C or 36-46°F). (Minimum Serum: 0.5 mL)

Rejection Criteria

  • Lipemic or icteric specimens.
  • Grossly hemolyzed specimens.

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers® with Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers® without Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 6 months

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Special Testing Laboratory

Performed

Monday - Friday.
Results available within 2 business days.

Reference Range

Age

Male (ng/mL)

Female (ng/mL)

0-12 months
1-3 years
4-5 years
6-7 years
8-9 years
10-11 years
12-13 years
14-15 years
16-17 years
18-19 years
20-24 years
25-29 years
30-34 years
35-39 years
40-44 years
45-49 years
50-54 years
55-59 years
60-64 years
65 years and older

1039-3169
972-4123  
1843-4968
1838-4968
1932-5858
1828-6592
2134-6598
2330-6550
2380-6400
2340-6632
2404-5948
2614-5792
2500-5806
2474-5208
2360-5560
2314-5700
2528-5050
2482-5460
2592-4770
2698-5688

1039-3169
1590-4225
2169-4790
2188-4996
2072-5504
2456-6992
2838-6846
2654-6680
2756-6908
2700-6492
3032-5992
2926-5858
2878-6650
2786-6084
2514-6014
2838-4954
2562-5596
2574-5914
2684-5130
2462-5274

Tanner Stage I
Tanner Stage II
Tanner Stage III
Tanner Stage IV & V

1878-6190
2112-6208
2372-6602
2336-6414

2314-6086
2732-6738
2870-7068
2756-7232

Test Methodology

Chemiluminescent Immunoassay

Clinical Utility

Insulin-like growth factors 1 and 2 (IGF-1, IGF-2) are small polypeptides involved in the regulation of cell growth.  IGF-1 and IGF-2 are bound to insulin-like growth factor binding proteins, six of which have been described.  IGFBP-3 is the predominant of these, binding ~95% of circulating IGF-1 and IGF-2. 

IGF-1 serves as the major mediator of the anabolic and growth-promoting effects of growth hormone.  Secretion patterns of IGF-1 and IGFBP-3 mirror each other, and are primarily growth hormone dependent.  In contrast to growth hormone production, which is pulsatile and demonstrates significant diurnal variation, IGF-1 and IGFBP-3 levels exhibit only minor fluctuations.  Given that, serum measurements of IGF-1 and IGFBP-3 represent a more stable assessment of growth hormone production, and aid in the evaluation of growth disorders and growth hormone deficiency.

CPT Code

82397

Last Updated

05/01/2018

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.