Saccharomyces Cerevisiae Ab, IgA
ASCA, Anti saccharomyces cerevisiae Antibody, Saccharomyces cerevisiae IgA Antibodies, Saccharomyces cerevisiae Antibody, IgA, Serum, Saccharomyces cerevisiae Antibodies, IgA, MAYO: AASCA, EPIC: LAB6645, SOFT: XSACA
Specimen Collection Criteria
Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Gold-top SST tube.
Physician Office/Drawsite Specimen Preparation
Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to plastic transport tube and refrigerate (2-8°C or 36-46°F).
Preparation for Courier Transport
Transport: 0.5 mL serum, refrigerated (2-8°C or 36-46°F). (Min: 0.4 mL)
- Specimens that are grossly lipemic.
- Specimens that are grossly hemolyzed.
- Specimens not collected and processed as indicated.
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): 21 days
Frozen (-20°C/-4°F or below): 21 days
Specimen Storage in Department Prior to Disposal:
Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.
Sent to Mayo Medical Laboratory, Rochester, MN.
Monday - Friday
Results available in 2-4 days.
Negative: 0.0-20.0 U.
Equivocal: 20.1-24.9 U.
Weakly positive: 25.0-34.9 U.
Positive: Greater than or equal to 35.0 U.
Enzyme-Linked Immunosorbent Assay (ELISA).
This test aids in differentiating Crohn's disease from ulcerative colitis.
Crohn's disease and ulcerative colitis are two types of inflammatory bowel disease. Crohn's disease usually affects the small intestine, however it can affect any part of the digestive tract and may be segmental. Ulcerative colitis causes inflammatory changes and ulcerations in the colon and rectum. Signs and symptoms of Crohn's disease and ulcerative colitis can be similar and diagnosis may be difficult.
Recent studies have shown that antisaccaromyces cerevisiae antibodies (ASCA) are more likely to occur in Crohn's disease than in ulcerative colitis or healthy controls. One study found the presence of both IgG and IgA ASCA was 100% specific for Crohn's disease, however not all patients with Crohn's disease have these antibodies.
A large proportion (approximately 70%) of patients with ulcerative colitis have been found to be positive for P-ANCA (perinuclear antineutrophilic cytoplasmic antibodies). Use of both ASCA and ANCA could assist in differentiating ulcerative colitis from Crohn's disease. The following table summarizes likelihood of positivity in ASCA and ANCA testing in Crohn's disease and ulcerative colitis.
||Less than 20% positive
||Less than 1% positive
MAYO: AASCA, EPIC: LAB6645, SOFT: XSACA
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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills,
Grosse Pointe, Royal Oak, and Troy campuses.