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Beaumont Laboratory

Venlafaxine and Metabolite

Effexor®, ARUP #2007957, EPIC: LAB6348, SOFT: XVENL

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Lavender-top EDTA tube.

Do not use Serum Separator Tubes.

Physician Office/Drawsite Specimen Preparation

Centrifuge to separate serum or plasma from cells within two hours collection. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Min: 0.5 mL)

Rejection Criteria

  • Serum Separator (SST) tubes.
  • Specimens not collected and processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 14 days
Refrigerated (2-8°C or 36-46°F): 14  days
Frozen (-20°C/-4°F or below): 14 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to ARUP Laboratories, Salt Lake City, UT.


Sunday, Wednesday.
Results available in 2-6 days.

Reference Range

Therapeutic Range: 195-400 ng/mL (total - venlafaxine and o-desmethylvenlafaxine).
Toxic Range: Not well established.

Test Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).


By report.

Clinical Utility

Effexor (venlafaxine hydrochloride) is an antidepressant for oral administration. It is indicated for the treatment of depression. This assay is used for the therapeutic monitoring and toxicity assessment of venlafaxine.

CPT Code

80338 alt G0480.

Test Codes

ARUP #2007957, EPIC: LAB6348, SOFT: XVENL

Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.