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Beaumont Laboratory

Hereditary Spherocytosis Evaluation

Osmotic Fragility, Routine Osmotic Fragility, Erythrocyte Osmotic Fragility (Routine), MAYO: RBCME, EPIC: LAB6270, SOFT: XHSPE


  • Due to specimen stability, patients should be drawn Monday-Thursday only. For questions, call the Laboratory at (800) 551-0488.
  • A control specimen from an unrelated, non-smoking individual must be collected and sent with the patient specimen.

Specimen Collection Criteria

Collect: One Lavender-top EDTA tube from the patient AND one Lavender-top EDTA tube from an unrelated individual as a control specimen. Indicate the control's sex on the control collection tube.

Send specimens for processing immediately after collection.

Physician Office/Drawsite Specimen Preparation

Do not centrifuge. Maintain whole blood specimens refrigerated (2-8°C or 36-46°F) prior to transport.

Preparation for Courier Transport

Transport: 4.0 mL whole blood for both patient and control specimens, refrigerated (2-8°C or 36-46°F). (Min: 2.0 mL each tube)

Rejection Criteria

  • Centrifuged specimens.
  • Hemolyzed specimens.
  • Specimens not collected and processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): 72 hours
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to Mayo Medical Laboratories, Rochester, MN.


Monday - Saturday.
Results available in 5-8 days.

Reference Range

By report.

Test Methodology

Osmotic Lysis/Flow Cytometry.

CPT Code

85557. Add 88184, if appropriate.

Test Codes


Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.