Lab Test

Desmoglein 1 (DSG1) and Desmoglein 3 (DSG3), Serum

Test Codes

MAYO: DSG13, EPIC: LAB6253, SOFT: XDESM

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Gold-top SST tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 14 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 30 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Medical Laboratories, Rochester, MN.

Performed

Varies.
Results available in 2-11 days

Reference Range

By report.

Test Methodology

Enzyme-Linked Immunosorbent Assay (ELISA).

Clinical Utility

Pemphigus includes a group of often fatal autoimmune, blistering diseases characterized by intraepithelial bullous lesions. Phemphigus vulgaris and its variants present with oral or mucosal lesions alone or with mucosal plus skin lesions. Phemphigus foliaceous and variants present with skin lesions alone. Both forms are caused by autoantibodies to cell surface antigens of stratified epithelia or mucous membranes and skin. Antibodies to Desmoglein 1 (DSG1) are present in pemphigus foliaceus and Desmoglein 3 (DSG3) and or DSG1 in pemphigus vulgaris.
Antibody titer correlates in a semiquatitative manner with disease activity in many patients.

CPT Codes

83516 x 2.
LOINC:  Desmoglein 1  43311-0, Desmoglein 3  43312-8

Contacts

Last Updated

7/7/2021

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