VWF Cleaving Protease Activity, Adams 13 Activity , Blood Center of Wisconsin: BCW1298, EPIC: LAB6509, SOFT: XADMA
Specimen Collection Criteria
Collect: One Light Blue-top Sodium Citrate tube.
Physician Office/Drawsite Specimen Preparation
Centrifuge to separate plasma from cells. Transfer plasma to plastic transport tube and freeze (-20°C/-4°F or below).
Preparation for Courier Transport
Transport: 0.5 mL plasma, frozen (-20°C/-4°F or below). (Min: 0.2 mL)
- Specimens collected in EDTA.
- Specimens not collected and processed as indicated.
Monday - Friday.
Results available in 3-5 days.
FRET-Based Kinetic Assay.
ADAMTS13 is a regulator of the interaction of platelets with von Willebrand factor. Absent or low ADAMTS13 activity appears to allow formation of platelet microthrombi, which in turn obstruct arterioles and capillaries. Low levels of ADAMTS13 are associated with a clinical diagnosis of Thrombotic thrombocytopenic purpura (TTP). Severe deficiency of less than 5% appears to be a relatively specific finding in thrombotic microangiopathy patients with a clinical diagnosis of TTP or Upshaw-Schulman Syndrome. Patients with low levels of activity and the presence of an inhibitor increase specificity for a diagnosis of idiopathic TTP.
Blood Center of Wisconsin: BCW1298, EPIC: LAB6509, SOFT: XADMA
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This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.