Lab Test

ADAMTS13 Activity

VWF Cleaving Protease Activity, Adams 13 Activity , Blood Center of Wisconsin: BCW1298, EPIC: LAB6509, SOFT: XADMA

Specimen Collection Criteria

Collect: One Light Blue-top Sodium Citrate tube.

Physician Office/Drawsite Specimen Preparation

Centrifuge to separate plasma from cells. Transfer plasma to plastic transport tube and freeze (-20°C/-4°F or below).

Preparation for Courier Transport

Transport: 0.5 mL plasma, frozen (-20°C/-4°F or below). (Min: 0.2 mL)

Rejection Criteria

  • Specimens collected in EDTA.
  • Specimens not collected and processed as indicated.

Performed

Monday - Friday.
Results available in 3-5 days.

Reference Range

By report.

Test Methodology

FRET-Based Kinetic Assay.

Clinical Utility

ADAMTS13 is a regulator of the interaction of platelets with von Willebrand factor. Absent or low ADAMTS13 activity appears to allow formation of platelet microthrombi, which in turn obstruct arterioles and capillaries. Low levels of ADAMTS13 are associated with a clinical diagnosis of Thrombotic thrombocytopenic purpura (TTP). Severe deficiency of less than 5% appears to be a relatively specific finding in thrombotic microangiopathy patients with a clinical diagnosis of TTP or Upshaw-Schulman Syndrome. Patients with low levels of activity and the presence of an inhibitor increase specificity for a diagnosis of idiopathic TTP.

CPT Code

85397.

Test Codes

Blood Center of Wisconsin: BCW1298, EPIC: LAB6509, SOFT: XADMA

Last Updated

7/11/2019

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This directory currently reflects information only for specimens collected and/or processed at the
Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.