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Beaumont Laboratory

Sex Hormone Binding Globulin

SHBG, testosterone binding capacity, Sex Hormone Binding Globulin, Antrim #32004, EPIC: LAB5818, SOFT: SHBG

Specimen Collection Criteria

Collect: One Gold-top SST tube.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged collection tube within two hours of collection. (Minimum Serum: 0.5 mL)

Preparation for Courier Transport

Transport: Centrifuged collection tube, refrigerated (2-8 °C or 36-46 °F). (Minimum Serum: 0.5 mL)

Rejection Criteria

  • Grossly hemolyzed, lipemic, or icteric specimens.

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers® with Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers® without Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 2 months

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Special Testing Laboratory

Performed

Monday - Friday.
Results available within 2 business days.

Reference Range

Age Male
(nmol/L)
Female
(nmol/L)
0-30 days 11-71 12-51
31-365 days 60-209 50-181
1-3 years 42-156 51-158
4-6 years 39-146 48-142
7-9 years 38-114 31-103
10-12 years 32-93 20-100
13-15 years 13-63 17-77
16-18 years 11-54 9-75
19-150 years 13-71 18-114

Test Methodology

Chemiluminescent Immunoassay.

Interpretation

Sex hormone binding globulin (SHBG) is a ß-globulin which transports testosterone, dihydrotestosterone (DHT), and estradiol in plasma. It tightly binds approximately 60% of plasma testosterone and DHT. Neither steroid is metabolically active in the bound form.

The sex hormone binding globulin (SHBG) assay can be useful in interpreting blood testosterone levels. Alterations in SHBG levels in certain disease states can result in measurements of testosterone which do not accurately reflect bioavailable levels.

Decreased SHBG levels may be found in obesity, hypothyroidism, androgen use, nephrotic syndrome, Cushing's disease, acromegaly, hirsutism, and polycystic ovary syndrome.

Increased SHBG levels may be increased in hepatic cirrhosis, hyperthyroidism, and estrogen use. Free testosterone levels are often more useful in these situations.

Clinical Utility

SHBG may be useful in the differential diagnosis of hirsutism and in the assessment of bioavailable testosterone.

Test Codes

Antrim #32004, EPIC: LAB5818, SOFT: SHBG

Last Updated

11/11/2016

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.