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Beaumont Laboratory

Haloperidol Level

Haldol, ARUP #99640, Antrim #82080, EPIC: LAB6046, SOFT: XHALP

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Lavendar-top EDTA tube.

Do not use Serum Separator Tubes.

Time of Collection: Trough, just prior to the next dose.

Physician Office/Drawsite Specimen Preparation

Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Min: 0.5 mL)

Rejection Criteria

  • Serum Separator (SST) tubes.
  • Specimens not collected and processed as indicated.

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 4 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 30 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Monday, Wednesday, Friday.
Results available in 2-6 days.

Reference Range

Therapeutic Range: 5.0-20.0 ng/mL.
Toxic Range: Greater than 42.0 ng/mL.

Test Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).

Interpretation

The upper limit of the haloperidol therapeutic range is not well defined. Some patients require higher plasma concentrations to achieve therapeutic effect and exhibit no toxicity, while others exhibit toxicity within the therapeutic range. To a greater extent than with many other drugs, dosage must be individualized to each patient. The lowest possible plasma concentration at which therapeutic effect is exhibited should be sought.

Clinical Utility

Haloperidol is a member of the butyrophenone class of neuroleptic drugs used to treat psychotic disorders (e.g., schizophrenia). It is also used to control the tics and verbal utterances associated with Tourette's syndrome and in the management of intensely hyperexcitable children who fail to respond to other treatment modalities. This assay is used for the therapeutic monitoring and toxicity assessment of haloperidol.

CPT Code

80173.

Test Codes

ARUP #99640, Antrim #82080, EPIC: LAB6046, SOFT: XHALP

Last Updated

05/04/2016

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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.