Lab results are too important to go anywhere else

Beaumont Laboratory

TSH Receptor Antibody (TRAb)

TBII, Thyrotropin Binding Inhibiting Immunoglobulins, Thyroid Stimulating, ARUP #2002734, EPIC: LAB6172, SOFT: XTRAB

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and freeze (-20°C/-4°F or below).

Preparation for Courier Transport

Transport: 1.0 mL serum, frozen (-20°C/-4°F or below). (Min: 0.3 mL)

Rejection Criteria

  • Lipemic specimens.
  • Grossly hemolyzed specimens.
  • Specimens not collected and processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 24 hours
Refrigerated (2-8°C or 36-46°F): 72 hours
Frozen (-20°C/-4°F or below): 1 month

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to ARUP Laboratories, Salt Lake City, UT.


Sunday - Saturday.
Results available in 2-4 days.

Reference Range

Less than or equal to 1.75 IU/L.

Test Methodology

Quantitative Electrochemiluminescent Immunoassay.


  • TSH Receptor Antibodies are measured in this assay by the thyrotropin binding inhibiting immunoglobulin technique (TBII). Results are reported as percent inhibition of TSH binding.
  • Positive results are consistent with autoimmune thyroid disease.

Clinical Utility

The TSH receptor antibody (TRAb) assay aids in the differential diagnosis of Graves' disease (positive in > 85%) versus toxic nodular goiter. TRAb levels aid the clinician in prescribing the most appropriate course of therapy upon initial diagnosis. This assay is also used to monitor the efficacy of anti-thyroid drug therapy to predict the likelihood of disease remission.

CPT Code


Test Codes

ARUP #2002734, EPIC: LAB6172, SOFT: XTRAB

Last Updated


Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.