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Beaumont Laboratory

Zinc Protoporphyrin (ZPP), Whole Blood, Industrial

ARUP #20614, EPIC: LAB6352, SOFT: XZPIN

Specimen Collection Criteria

Collect (preferred specimen): One Lavender-top EDTA tube.
Also acceptable: One Royal Blue-top EDTA tube.

Physician Office/Drawsite Specimen Preparation

Do not centrifuge or freeze. Maintain whole blood refrigerated (2-8°C or 36-46°F) prior to transport.

Preparation for Courier Transport

Transport: 1.0 mL whole blood, refrigerated (2-8°C or 36-46°F). (Min: 0.2 mL)

Rejection Criteria

  • Centrifuged specimens.
  • Frozen specimens.
  • Clotted specimens.
  • Hemolyzed specimens.
  • Specimens not collected and processed as indicated. 

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 30 hours
Refrigerated (2-8°C or 36-46°F): 5 weeks
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Monday - Friday.
Results available in 2-5 days.

Reference Range

Zinc Protoporphyrin (ZPP), Blood: 0-40 mcg/dL.
Zinc Protoporphyrin (ZPP) to Heme Ratio: 0-69 mcmol ZPP/mol heme.

Test Methodology

Quantitative Hematofluorometry.

Interpretation

For occupational exposure to lead, OSHA requires ZPP whole blood testing reported in units of mcg/dL. For adults, conversion of ZPP units of mcg/dL assumes a hematocrit of 45%.

Clinical Utility

Elevated ZPP results are seen in early and late iron deficiency, in the anemia of chronic disease erythropoietic protoporphyria, and in chronic lead poisoning (typically when blood lead is greater than 25 mcg/dL). Causes for false elevations include markedly elevated bilirubin and riboflavin. Elevated protoporphyrin (as in erythropoietic protoporphyria) can also increase the ZPP signal. Specimens which are hemolyzed, clotted, or improperly aliquoted can also show false elevations.

CPT Code

84202.

Test Codes

ARUP #20614, EPIC: LAB6352, SOFT: XZPIN

Last Updated

12/19/2016

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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.