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Beaumont Laboratory

Lysozyme, Plasma

Muramidase, MAYO: MUR, EPIC: LAB6090, SOFT: XLYSO

Specimen Collection Criteria

Collect: One Lavender-top EDTA tube.

Send specimen for processing immediately after collection.

Physician Office/Drawsite Specimen Preparation

Critical frozen. Centrifuge to separate plasma from cells immediately. Transfer plasma to a plastic transport tube and freeze (-20°C/-4°F or below) immediately.

Preparation for Courier Transport

Transport: 2.0 mL plasma, frozen (-20°C/-4°F or below). (Min: 1.0 mL)

Rejection Criteria

  • Specimens not collected and processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): 30 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to Mayo Medical Laboratories, Rochester, MN.


Monday - Friday.
Results available in 3-6 days.

Reference Range

By report.

Test Methodology



Levels greater than 200 mcg/mL may be seen in acute nonlymphocytic leukemia (M2, M4, M5) or chronic granulocytic leukemias.

Clinical Utility

Lysozyme levels may be elevated in acute myelomonocytic leukemia (FAB-M4), chronic myelomonocytic leukemia (CMML) and chronic myelocytic leukemia (CML). Increased serum lysozyme activity is present in tuberculosis, sarcoidosis, megaloblastic anemias, acute bacterial infections, ulcerative colitis, regional enteritis and Crohn's disease. Elevated levels of lysozyme occur during severe renal insufficiency, renal transplant rejection, urinary tract infections, pyelonephritis, glomerulonephritis and nephrosis.

CPT Code


Test Codes


Last Updated


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UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.