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Beaumont Laboratory

Methsuximide/Normethsuximide

Celontin, ARUP #2011531, EPIC: LAB6101, SOFT: XMSX

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Lavender-top EDTA tube.

Do not use Serum Separator Tubes.

Time of Collection: Trough, just prior to the next dose.

Physician Office/Drawsite Specimen Preparation

Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Min: 0.5 mL)

Rejection Criteria

  • Serum Separator (SST) tubes.
  • Specimens not collected or processed as indicated.

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 5 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 1 month

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Monday, Thursday.
Results available the 2-6 days.

Reference Range

Therapeutic Ranges:

Methsuximide: Less than 1 mcg/mL.
Normethsuximide: 10-40 mcg/mL.

Total: 10-40 mcg/mL.
Toxic Total: Greater than 60 mcg/mL.

Test Methodology

Quantitative Gas Chromatography / Mass Spectrometry.

Interpretation

By report.

Clinical Utility

Methsuximide is an anticonvulsant indicated for the control of absence (petit mal) seizures that are refractory to other drugs. The methsuximide assay is used to optimize dosage, monitor compliance, and assess toxicity. Normethsuximide is an active metabolite of methsuximide.

CPT Code

80339, (AH G0480).

Test Codes

ARUP #2011531, EPIC: LAB6101, SOFT: XMSX

Last Updated

12/12/2016

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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.