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Beaumont Laboratory

Hemoglobin F

EPIC: LAB5860, SOFT: HGBF

Specimen Collection Criteria

Collect: One Lavender-top EDTA tube. (Min: 2.0 mL)
Also acceptable (Pediatric): One 500 mcL Lavender-top EDTA microtainer. (Min: 300 mcL)

Physician Office/Drawsite Specimen Preparation

Do not centrifuge. Do not freeze. Store whole blood refrigerated (2-8°C or 36-46°F) prior to transport. (Min: 2.0 mL)

Preparation for Courier Transport

Transport: Whole blood specimen, refrigerated (2-8°C or 36-46°F). (Min: 2.0 mL)

Rejection Criteria

  • Centrifuged specimens.
  • Frozen specimens.
  • Severely hemolyzed samples.

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 48 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Special Testing Laboratory.

Performed

Sunday, Wednesday, Friday.
Results available within 3 days.

Reference Range

0-30 days 60-90%
31 days - 23 months Less than 60%
24 months - Adult 0-2%

Test Methodology

High Performance Liquid Chromatography (HPLC).

Interpretation

Hgb F levels are much higher in the neonate than an older child or adult. Hgb F may be slightly increased in ß thalassemia trait (up to 10%) and moderately increased in delta-beta thalassemia (up to 20%). It is also increased in hereditary persistence of fetal hemoglobin, a condition most commonly seen in African-Americans. Slight increases may also be acquired and can occur with several bone marrow abnormalities (e.g., leukemias, aplastic anemia), severe anemias, with hydroxyurea therapy and in pregnancy.

Clinical Utility

This assay is used to quantitate the percent of fetal hemoglobin in the specimen. It aids in the diagnosis of disorders with elevated levels of fetal hemoglobin and various hemoglobinopathies.

CPT Code

83021.

Test Codes

EPIC: LAB5860, SOFT: HGBF

Last Updated

10/13/2016

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.