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Beaumont Laboratory

LD (Lactate Dehydrogenase), Blood

Lactate Dehydrogenase, LDH, Antrim #17268, EPIC: LAB5080, SOFT: LD

Instructions

For CSF and other fluid specimens, please see LD, Fluid.

Specimen Collection Criteria

Collect: One Gold-top SST tube.

Contact the Laboratory for acceptability of other tube types.

Physician Office/Drawsite Specimen Preparation

Let SST specimens clot 30-60 minutes then immediately centrifuge to separate serum from cells. It is preferable to leave the specimen at room temperature (20-26°C or 68-78.8°F) prior to transport. However, if the specimen requires other tests, the specimen can be refrigerated (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: Centrifuged SST tube, at room temperature (20-26°C or 68-78.8°F) (preferred), or refrigerated (2-8°C or 36-46°F). (Min: 0.5 mL)

Rejection Criteria

  • Hemolyzed specimens (unless the patient is known to have in-vivo hemolysis).
  • Red-top tubes with serum not separated from cells within two hours of collection. 

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers® with Separator Gel
Room Temperature (20-26°C or 68-78.8°F): 2-4 hours
Refrigerated (2-8°C or 36-46°F): 48 hours
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers® without Separator Gel
Room Temperature (20-25°C or 68-77°F): 2-4 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 7 days (preferred)
Refrigerated (2-8°C or 36-46°F): 48 hours
Frozen (-20°C/-4°F or below): 7 days

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days*

*Add-on requests for Lactate Dehydrogenase will only be honored if less than 48 hours have elapsed since the specimen collection time. 

Laboratory

Farmington Hills Chemistry Laboratory.
Grosse Pointe Chemistry Laboratory.
Royal Oak Automated Chemistry Laboratory.
Troy Chemistry Laboratory.

Performed

Sunday - Saturday, 24 hours a day.
STAT results available within 1 hour of receipt in the Laboratory.
Routine results available within 4 hours.

Reference Range

Age Male (U/L) Female (U/L)
0 - 30 days 125 - 735 145 - 765
31 days - 12 months 170 - 450 190 - 420
13 months - 3 years 155 - 345 165 - 395
4 - 6 years 155 - 345 135 - 345
7 - 9 years 145 - 300 140 - 280
10 - 12 years 120 - 325 120 - 260
13 - 15 years 120 - 290 100 - 275
16 - 18 years 105 - 235 105 - 230
19 years and older 100 - 238 100 - 238

Test Methodology

Enzymatic, Spectrophotometry.

Interpretation

Increased levels are found in a variety of conditions, including ischemic necrosis, meningitis, leukemia, metastatic tumors.

Clinical Utility

Lactate dehydrogenase is present in multiple cells and tissue types and therefore its utility in patient diagnosis is questionable. It is useful in the assessment of in-vivo hemolysis and hematologic disorders (benign and malignant) conditions in which LD is often increased. LD is also increased following myocardial infarction, pulmonary and renal cortical infarction, liver disease, skeletal muscle disease, and many other conditions. Use of more specific enzymes and protein markers is preferable to LD in the diagnosis of myocardial infarction (use Troponin or CK-MB), skeletal muscle (use CK) and liver disease.

CPT Code

83615.

Test Codes

Antrim #17268, EPIC: LAB5080, SOFT: LD

Last Updated

12/06/2017

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.