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Beaumont Laboratory

Troponin I

Cardiac Troponin, TnI, Antrim #16950, EPIC: LAB7028, SOFT: TROPG

Specimen Collection Criteria

Collect: One Light Green-top PST tube (Lithium Heparin plasma gel separator tube). (Minimum Whole Blood: 2.0 mL)

Do NOT use Gold-top Serum Separator (SST) tubes, Dark Green-top Lithium or Sodium Heparin tubes, Red-top serum tubes, or Lavender-top EDTA tubes.

Note: Patient Preparation (Grosse Pointe, Royal Oak & Troy ONLY): Twenty-four (24) hours before this test, the patient should not take multivitamins or dietary supplements containing biotin (vitamin B7) which is commonly found in hair, skin and nail supplements and multivitamins.

Physician Office/Drawsite Specimen Preparation

Invert PST tubes 8 times for proper mixing of heparin anticoagulant, then centrifuge immediately to separate plasma from cells, 1300 x g for 10 minutes (e.g., Drucker horizon mini E centrifuge). Refrigerate (2-8°C or 36-46°F) the centrifuged PST tube. (Min: 1.0 mL plasma)

Preparation for Courier Transport

Transport: Centrifuged PST tube, refrigerated (2-8°C or 36-46°F). (Min: 1.0 mL plasma)

Rejection Criteria

  • Light Green-top PST tubes with plasma not separated from cells within two hours of collection.
  • Specimens collected in inappropriate collection tubes.
  • Specimens not collected and processed as indicated.


Specimen Stability for Testing:

Centrifuged PST Tubes
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 48 hours
Frozen (-20°C/-4°F or below): Unacceptable

Plasma Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 48 hours
Frozen (-20°C/-4°F or below): 8 weeks

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days


Farmington Hills Chemistry Laboratory.
Grosse Pointe Chemistry Laboratory.
Royal Oak Automated Chemistry Laboratory.
Troy Chemistry Laboratory.


Sunday - Saturday, 24 hours a day.
STAT results available within 1 hour of receipt in the Laboratory.
Routine results available within 4 hours.

Reference Range

Less than 0.06 ng/mL Normal
0.06-0.19 ng/mL Indeterminate
Greater than or = 0.20 ng/mL Suggestive of Myocardial Damage

Samples with results greater than 40 ng/mL will not be diluted and will be reported as "greater than 40.00 ng/mL."

Test Methodology

Chemiluminescence Immunoassay.


Patients routinely exposed to animals or to animal serum products may develop heterophilic antibodies that can interfere with test results. Erroneous findings may also be obtained from samples taken from patients who have been treated with monoclonal mouse antibodies or have received them for diagnostic purposes.

Studies have shown that in the absence of an apparent acute coronary syndrome, an elevated level of either troponin T or troponin I in end stage renal disease is associated with an increased risk of mortality.

Please Note: Large doses of biotin (vitamin B7) may falsely decrease results for troponin-I.

Clinical Utility

Increases in troponin I occur in acute coronary syndromes with myocardial necrosis as well as myocardial infarction with ST elevation. Troponin I is detectable about 3-4 hours after the occurrence of cardiac symptoms. Following acute myocardial ischemia, troponin I remains in the serum for several days and can help to detect myocardial events that have occurred up to 7-10 days earlier.

Increases are also associated with direct myocardial damage (e.g., myocarditis, pericarditis, contusion, cardioversion), myocardial strain (e.g., CHF, pulmonary hypertension, pulmonary embolus) and demand ischemia (e.g., sepsis, hypotension, atrial fibrillation). Troponin may also be elevated in entities such as renal failure, intracranial hemorrhage and amyloidosis. The mechanism for the latter elevations is unclear. An elevated troponin level is a predictor for poor outcome regardless of its cause.

CPT Code


Test Codes

Antrim #16950, EPIC: LAB7028, SOFT: TROPG

Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.