800-551-0488

Lab results are too important to go anywhere else

Beaumont Laboratory

Sjogren SSB Antibody

Sjogren, anti-La, La Antibodies, SSB Antibodies, Antrim #30949, EPIC: LAB5768, SOFT: SJBA

Specimen Collection Criteria

Collect: One Gold-top SST tube.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged collection tube within two hours of collection. (Minimum Serum: 0.5 mL)

Preparation for Courier Transport

Transport: Centrifuged collection tube, refrigerated (2-8°C or 36-46°F). (Minimum Serum: 0.5 mL)

Rejection Criteria

  • Plasma specimens.
  • Heat-inactivated specimens.
  • Severely lipemic or hemolyzed specimens.

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers® with Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers® without Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 2 months

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Special Testing Laboratory

Performed

Monday, Wednesday, Friday.
Results available within 2 business days.

Reference Range

Negative: Less than 100 AU/mL.
Equivocal: 100-120 AU/mL.
Positive: Greater than 120 AU/mL.

Test Methodology

Multiplex Bead Immunoassay.

Interpretation

SSB antibodies are seen in 50-60% of Sjogren's and are specific if they are the only antibodies present. Fifteen to twenty-five percent of SLE and 5-10% of progressive systemic sclerosis patients are also positive.

The presence of anti-SSB antibodies is associated more frequently with a milder form of autoimmune disease and their detection can aid in the diagnosis and therapy of rheumatic diseases.

SLE patients that produce both SSA and SSB antibodies have a much lower incidence of nephritis than those patients producing anti-SSA antibodies alone.

Clinical Utility

SSB antibody assay is used to aid in the diagnosis and prognosis of certain rheumatic autoimmune diseases. Several studies point to the use of SSB antibodies as a serological marker for SS-sicca complex, as SSB antibodies are detected in approximately 60% of such patients.

CPT Code

86235

Test Codes

Antrim #30949, EPIC: LAB5768, SOFT: SJBA

Last Updated

05/18/2016

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.