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Beaumont Laboratory

Toxoplasma IgG

Toxoplasma Antibody, IgG, EPIC: LAB6891, SOFT: TOXIG

Specimen Collection Criteria

Collect: One Gold-top SST tube.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged collection tube within two hours of collection. (Minimum Serum: 0.5 mL)

Preparation for Courier Transport

Transport: Centrifuged collection tube, refrigerated (2-8 °C or 36-46 °F). (Minimum Serum: 0.5 mL)

Rejection Criteria

  • Lipemic, icteric, or grossly hemolyzed specimens. 

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers® with Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 72 hours
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers® without Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 6 months

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Special Testing Laboratory.

Performed

Tuesday, Friday.
Results available in 2 business days.

Reference Range

Negative: Less than 7.2 IU/mL.
Equivocal: 7.2-8.7 IU/mL.
Positive: Greater than or equal to 8.8 IU/mL.

Test Methodology

Chemiluminescent Immunoassay.

Interpretation

  • Positive: A result greater than or equal to 8.8 IU/mL is indicative of a past infection.
  • Negative: A result less than 7.2 IU/mL is considered to be negative and suggestive of no prior exposure.
  • Equivocal: For a result between 7.2 and 8.7 IU/mL, consider repeat testing.

Clinical Utility

This assay is used for the qualitative measurement of IgG antibodies to Toxoplasma gondii in human serum or plasma to determine an acute or past infection.

Clinical Disease

The causative agent of Toxoplasmosis is Toxoplasma gondii, a small intracellular protozoan parasite. Eighty to ninety percent of Toxoplasma infections are asymptomatic. Symptomatic patients may present with cervical lymphadenopathy, fever, sore throat, malaise, rash, or hepatosplenomegaly. Immunodeficient patients may have systemic infection, pneumonia, chorioretinitis, or CNS manifestations such as abscesses, encephalopathy, or encephalitis. Toxoplasmosis during pregnancy may cause spontaneous abortion or disease in the infant with symptoms developing after birth (2).

Epidemiology

Toxoplasmosis occurs worldwide. Asymptomatic infections are common. Serological surveys show that 7 to 80% of various populations are infected. The developing fetus and immunocompromised patients are at risk for severe disease (1).

Transmission

Transmission may occur transplacentally, by ingestion of raw or undercooked meat containing tissue cysts, or by exposure to oocysts in soil contaminated with cat feces (1).

Reference

  1. Berkow R, Fletcher A. The Merck Manual of Diagnosis and Therapy 16th edition, Merck Research Laboratories, Rahway, N.J., 1992.
  2. Bakerman S. Bakerman's ABC's of Interpretive Laboratory Data 3rd edition, Interpretive Laboratory Data, Inc., Myrtle Beach, SC, 1994.

CPT Code

86777.

Test Codes

EPIC: LAB6891, SOFT: TOXIG

Last Updated

04/28/2017

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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.