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Beaumont Laboratory

Haptoglobin

EPIC: LAB5066, SOFT: HAPTO

Specimen Collection Criteria

Collect: One Gold-top SST tube. (Minimum Whole Blood: 4.0 mL)

Contact the Laboratory for the acceptability of other tube types.

Physician Office/Drawsite Specimen Preparation

Let SST specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged SST tube within two hours of collection.

Preparation for Courier Transport

Transport: Centrifuged SST tube, refrigerated (2-8°C or 36-46°F). (Min: 0.5 mL)

Rejection Criteria

  • Plasma specimens.
  • Severely lipemic or hemolyzed specimens.
  • Red-top tubes with serum not separated from cells within two hours of collection.

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers® with Separator Gel
Room Temperature (20-26°C or 68-78.8°F): 2-4 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers® without Separator Gel
Room Temperature (20-25°C or 68-77°F): 2-4 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 2-4 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 7 days

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Farmington Hills Chemistry Laboratory.
Royal Oak Automated Chemistry Laboratory.

Performed

Farmington Hills

Sundays – Saturday, day shift only.

Royal Oak

Sunday - Saturday, 24 hours a day.
STAT results available within 1 hour of receipt in the Laboratory.
Routine results available within 4 hours.

Reference Range

40-240 mg/dL.
Newborns reach adult levels at about 4 months of age.

Test Methodology

Immunoturbidimetry.

Interpretation

Haptoglobin is decreased in hemolysis, significant liver disease, and less commonly in genetic deficiencies (anhaptoglobinemia, hypohaptoglobinemia). Levels are increased in acute inflammation and with estrogen (oral contraceptive, pregnancy, hormone replacement therapy), androgen and glucocorticoid treatment.

Clinical Utility

Haptoglobin binds to hemoglobin released into the circulation by intravascular hemolysis. Haptoglobin is an acute phase reactant. Serial assays are used to detect and monitor hemolytic states. Haptoglobin is decreased in diseases associated with intravascular hemolysis. In severe hemolysis, haptoglobin may be totally depleted, requiring up to 1 week to return to normal. In chronic hemolytic states such as hemoglobinopathies and mechanical heart valves, there may be a steady decline in haptoglobin levels. In these conditions, serial assays provide a better index of ongoing hemolysis than a single haptoglobin value.

Increased serum haptoglobin levels are present in infection, neoplasia, and other inflammatory conditions characterized by tissue injury and repair.

CPT Code

83010.

Test Codes

EPIC: LAB5066, SOFT: HAPTO

Last Updated

02/08/2017

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.