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Beaumont Laboratory

Tissue Transglutaminase Antibody, IgG

tTG IgG, WARDE: TTGG, EPIC: LAB6163, SOFT: XTTGG

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and freeze (-20°C/-4°F or below) .

Preparation for Courier Transport

Transport: 1.0 mL serum, freeze (-20°C/-4°F or below). (Min 0.5 mL)

Rejection Criteria

  • Hemolyzed specimens.
  • Grossly lipemic specimens.
  • Specimens not collected and processed as indicated.

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 48 hours
Frozen (-20°C/-4°F or below): 14 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.

Laboratory

Sent to Warde Medical Laboratory, Ann Arbor, MI.

Performed

Monday - Friday.
Results available in 2-4 days.

Reference Range

None Detected: Less than 20 EU.
Weakley Positive: 20-30 EU.
Positive: Greater than 30 EU.

Test Methodology

Enzyme-Linked Immunosorbent Assay (ELISA).

Clinical Utility

Gluten-sensitive enteropathy is characterized as a non-allergic hypersensitivity to gluten or storage proteins found in wheat and other cereals. This hypersensitivity causes intestinal villous atrophy resulting in malabsorption. The Tissue Transgutenase IgG (tTG IgG) assay may aid in the diagnosis of gluten-sensitivity enteropathy (i.e., celiac disease, dermatitis herpetiformis) in tTG IgA negative patients with confirmed IgA deficiency. A negative tTG IgG test alone does not rule out gluten-sensitive enteropathy.

CPT Code

83516.

Test Codes

WARDE: TTGG, EPIC: LAB6163, SOFT: XTTGG

Last Updated

07/16/2017

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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.