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Beaumont Laboratory

Insulin Like Growth Factor Binding Protein 3

IGF Binding Protein 3, IGFBP3, LabCorp #500644, Esoterix #500281, EPIC: LAB6071, SOFT: XIBP3

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within one hour of collection. Transfer serum to a plastic transport tube and freeze (-20°C/-4°F or below).

Preparation for Courier Transport

Transport: 1.0 mL serum, frozen (-20°C/-4°F or below). (Min: 0.2 mL)

Rejection Criteria

  • Specimens not collected and processed as indicated.


Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 14 days
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 14 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.


Sent to LabCorp Esoterix Endocrinology, Calabassas Hills, CA.


Monday - Friday.
Results available within 4-6 days.

Reference Range

By report.

Test Methodology

RIA in dilute serum.

Clinical Utility

Circulating insulin-like growth factor-1 (IGF-1) is almost totally bound to high affinity binding proteins called IGF binding proteins, (IGFBPs). Six IGFBPs have been identified, IGFBP3 is the major carrier of IGFs in serum and is present in the highest concentrations. More than 90% of IGF-1 and IGF-2 is bound to IGFBP3 and the complex in humans has a half life of 12-15 hours.

IGFBP3 may provide a storage pool for IGF-1 and may be involved in transport of IGF-1 to tissues. Serum concentrations of IGFBP3 are fairly constant throughout the day and are controlled by GH and IGF-1 levels.

The measurement of IGFBP3 is useful in the evaluation of several clinical situations:

  • short stature in children.
  • acromegaly.
  • nutritional status.

CPT Code


Test Codes

LabCorp #500644, Esoterix #500281, EPIC: LAB6071, SOFT: XIBP3

Last Updated


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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.