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Beaumont Laboratory

Monoclonal Gammopathy Evaluation, Serum

Serum Monoclonal Gammopathy Evaluation, Antrim #32036, EPIC: LAB5871, SOFT: SMGE

Specimen Collection Criteria

Collect: One Gold-top SST tube. (Minimum Whole Blood: 4.0 mL)

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Transfer serum to a plastic aliquot tube and refrigerate (2-8°C or 36-46°F) within 8 hours of collection. (Min: 1.0 mL)

Preparation for Courier Transport

Transport: Serum aliquot tube, refrigerated (2-8°C or 36-46°F). (Min: 1.0 mL)

Rejection Criteria

  • Plasma specimens.
  • Severely lipemic or hemolyzed samples.

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes
Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes, and Microtainers®

Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 8 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 1 month

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Special Testing Laboratory

Performed

Monday - Friday.
Results available within 3 business days.

Reference Range

See the Chemistry Department’s reference ranges for Total Protein.

Age

Albumin

Alpha-1
Globulins

Alpha-2
Globulins

Beta
Globulins

Gamma Globulins

0-6 Days

2.19-3.26

0.18-0.51

0.26-0.62

0.35-0.56

0.81-1.67

7-15 Days

3.41-4.80

0.18-0.51

0.26-0.62

0.35-0.56

0.81-1.67

16 Days-12 Month

3.41-4.80

0.18-0.51

0.43-0.94

0.43-0.84

0.58-1.55

13 Months-5 Years

3.41-4.80

0.18-0.68

0.43-1.25

0.43-1.03

0.58-2.03

6-16 Years

3.50-5.09

0.18-0.68

0.43-1.25

0.43-1.03

0.58-2.03

17 Years and older

3.42-4.86

0.22-041

0.55-1.09

0.53-1.01

0.60-1.45

 

Monoclonal protein: Negative

Test Methodology

Capillary Protein Electrophoresis and Immunofixation Electrophoresis.

Interpretation

Capillary Electrophoresis is performed with quantitation of any monoclonal protein detected. A complete immunofixation is also performed. Immunoglobulin quantitations are performed on initial diagnosis of a monoclonal protein, and on follow-up when quantitation by scan is not possible. Immunoglobulin quantitation is also performed with initial diagnosis of hypogammaglobulinemia. If only a small amount of monoclonal protein is present in the beta globulin region, quantitation may not be possible and following the affected immunoglobulin level is the best way to monitor a patient. If the patient has a free kappa or lambda monoclonal protein, use of the free light chain assay to monitor the monoclonal protein quantitation, is recommended.

Reflex Testing

  • Run SPE and immunofixation.
  • If new abnormality, run complete immunofixation and immunoglobulin quantitations.

Clinical Utility

It is suggested that this test be ordered for patients suspected of having a monoclonal gammopathy. If a monoclonal protein is detected, it will be identified and quantified automatically.

CPT Code

84165, 86334 with reflex to 82784x3.

Test Codes

Antrim #32036, EPIC: LAB5871, SOFT: SMGE

Last Updated

11/28/2017

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.