Methylmalonic Acid (MMA), Serum Quantitative
MMA, MAYO: MMAS, EPIC: LAB6102, SOFT: XMMA
Specimen Collection Criteria
Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Gold-top SST tube.
Physician Office/Drawsite Specimen Preparation
Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).
Preparation for Courier Transport
Transport: 1.5 mL serum, refrigerated (2-8°C or 36-46°F). (Min: 0.5 mL)
- Specimens not collected and processed as indicated.
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): 48 days
Refrigerated (2-8°C or 36-46°F): 48 days
Frozen (-20°C/-4°F or below): 48 days
Specimen Storage in Department Prior to Disposal:
Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.
Sent to Mayo Medical Laboratories, Rochester, MN.
Monday - Friday.
Results available in 4-6 days.
Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS).
Elevated methylmalonic acid is an early and sensitive indicator of vitamin B12 (cobalamin) deficiency. Renal insufficiency and intravascular volume contraction can also elevate serum methylmalonic acid modestly (typically less than 1.0 mcmol/L).
Homocystine is an additional metabolite which is elevated in vitamin B12 deficiency, although homocystine is also elevated in folic acid and vitamin B6 deficiencies, as well.
This assay aids in the diagnosis of megaloblastic anemia. Elevated methylmalonic acid levels provide an early indication of cobalamin (B12) deficiency.
It is also useful for evaluating children with signs and symptoms of methylmalonic acidemia.
Cautions: Diet, nutritional status, and age should be considered in the evaluation of serum MMA level.
MAYO: MMAS, EPIC: LAB6102, SOFT: XMMA
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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills,
Grosse Pointe, Royal Oak, and Troy campuses.