Valproic Acid, Free
Depakene®, Depakote®, Valproate, Valproex®, ARUP #99310, EPIC: LAB6173, SOFT: XVALF
Specimen Collection Criteria
Collect: One plain Red-top tube.
Do not use Serum Separator Tubes.
Time of Collection: Trough, just prior to the next dose.
Physician Office/Drawsite Specimen Preparation
Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).
Preparation for Courier Transport
Transport: 2.0 mL serum, refrigerated (2-8°C or 36-46°F). (Min: 1.0 mL)
- Specimens not collected and processed as indicated.
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): 24 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 1 month
Specimen Storage in Department Prior to Disposal:
Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.
Sent to ARUP Laboratories, Salt Lake City, UT.
Tuesday - Saturday.
Results available within 2-5 days.
Total Valproic Acid, Therapeutic: 50-125 mcg/mL.
Total Valproic Acid, Toxic: Greater than 150 mcg/mL.
Free Valproic Acid, Therapeutic: 7-23 mcg/mL.
Free Valproic Acid, Toxic: Greater than 30 mcg/mL.
Percent Free Valproic Acid: 5-18 percent.
Quantitative Enzyme Multiplied Immunoassay Technique.
Free valproic acid may be important to monitor in patients with altered or unpredictable protein binding capacity because valproic acid exhibits variable, dose-dependent protein binding. Valproic acid is also subject to drug-drug interactions due to displacement of protein binding. Calculating percent free attempts to minimize differences in assay cross-reactivity and may be useful in dose optimization.
ARUP #99310, EPIC: LAB6173, SOFT: XVALF
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This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills,
Grosse Pointe, Royal Oak, and Troy campuses.