800-551-0488

Lab results are too important to go anywhere else

Beaumont Laboratory

Valproic Acid, Free

Depakene®, Depakote®, Valproate, Valproex®, ARUP #99310, EPIC: LAB6173, SOFT: XVALF

Specimen Collection Criteria

Collect: One plain Red-top tube.

Do not use Serum Separator Tubes.
Time of Collection: Trough, just prior to the next dose.

Physician Office/Drawsite Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 2.0 mL serum, refrigerated (2-8°C or 36-46°F). (Min: 1.0 mL)

Rejection Criteria

  • Specimens not collected and processed as indicated.

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 24 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 1 month

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Sendout Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Tuesday - Saturday.
Results available within 2-5 days.

Reference Range

Total Valproic Acid, Therapeutic: 50-125 mcg/mL.
Total Valproic Acid, Toxic: Greater than 150 mcg/mL.
Free Valproic Acid, Therapeutic: 7-23 mcg/mL.
Free Valproic Acid, Toxic: Greater than 30 mcg/mL.
Percent Free Valproic Acid: 5-18 percent.

Test Methodology

Quantitative Enzyme Multiplied Immunoassay Technique.

Interpretation

Free valproic acid may be important to monitor in patients with altered or unpredictable protein binding capacity because valproic acid exhibits variable, dose-dependent protein binding. Valproic acid is also subject to drug-drug interactions due to displacement of protein binding. Calculating percent free attempts to minimize differences in assay cross-reactivity and may be useful in dose optimization.

CPT Code

80165

Test Codes

ARUP #99310, EPIC: LAB6173, SOFT: XVALF

Last Updated

12/19/2016

Microtainer® and Vacutainer® are registered trademarks of Becton, Dickinson and Company.
UroVysion® is a registered trademark of Abbott Laboratories. ThinPrep® is a registered trademark of Hologic, Incorporated.

This directory currently reflects information only for specimens collected and/or processed at the Farmington Hills, Grosse Pointe, Royal Oak, and Troy campuses.