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Voriconazole

Voriconazole Level

Test Codes

VFed, EPIC: LAB7167, SOFT: VORIC

Department

Toxicology

Specimen Collection Criteria

Collect: One plain red top tube. (Minimum Whole Blood: 2.0 mL, serum 1.0 mL)

Do not use Serum Separator Tubes.
Time of Collection: Trough, just prior to next dose.

Physician Office/Draw Specimen Preparation

Do not centrifuge. Maintain whole blood in original collection tube at room temperature (20-26°C or 68-78.8°F) prior to transport.

Preparation for Courier Transport

Transport: Whole blood in original collection tube at room temperature (20-26°C or 68-78.8°F). (Minimum: 2.0 mL)

Rejection Criteria

Serum Separator (SST) tubes.  

In-Lab Processing

Do not centrifuge specimen. Deliver immediately to the appropriate testing station.

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 3 months

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 3 days
Frozen (-20°C/-4°F or below): 3 months

Laboratory

Royal Oak Toxicology Laboratory

Performed

Sunday – Saturday.
Results available within 24 hrs.

Reference Range

1.0-6.0 mcg/mL

Critical: >6.0 mcg/mL

Test Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS).

This test was developed and its performance characteristics determined by Beaumont Health. It has not been cleared or approved by the FDA. The Laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes and should not be regarded as investigational or for research.

Clinical Utility

Monitoring trough levels of voriconazole is suggested in individuals with reduced liver function, individuals with CYP2C19 polymorphisms associated with poor metabolic function, patients taking other medications that affect CYP2C19 activity, and in patients experiencing potential toxicity. Monitoring trough levels may be reasonable in patients who are not responding optimally or have drug interactions that may decrease voriconazole levels, or to ensure adequate oral absorption. 

Adverse effects of voriconazole include visual disturbances, skin rashes, and elevated liver enzyme levels.

CPT Codes

80285
LOINC: 38370-3, 35863-0

Contacts

Last Updated

1/17/2023