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Quinidine Level

Quinidine Level, Duraquin, Cardioquin

Test Codes

Order as a Miscellaneous Send Out. NMS: 4071SP

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Lavender-top tube.

Do not use Serum Separator Tubes.
Time of Collection: Trough, just prior to the next dose.
Record the exact time of specimen collection on the tube or in the computer system.

Physician Office/Draw Specimen Preparation

Centrifuge to separate serum or plasma from cells. Transfer serum or plasma to plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Rejection Criteria

• Serum Separator (SST) tubes.
• Hemolyzed specimens.
• Specimens not collected and processed as indicated.

In-Lab Processing

Centrifuge to separate serum or plasma from cells. Transfer serum or plasma to plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 24 hours
Refrigerated (2-8°C or 36-46°F): 30 days
Frozen (-20°C/-4°F or below): 365 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT. Forwarded to NMS Labs in Horsham, Pennsylvania.

Performed

Results available in 8-10 days.

Reference Range

By report.

Test Methodology

High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS).

Interpretation

Quinidine is eliminated by both renal and metabolic processes, therefore kidney or liver disease or advanced age could impair clearance and increase serum or plasma concentrations.

Clinical Utility

Quinidine is a naturally occurring alkaloid which is used to treat both atrial and ventricular arrhythmias cardiac arrhythmias. Quinidine has a narrow therapeutic index and the therapeutic and toxic effects have been shown to be related to quinidine serum concentrations. To obtain optimum therapy, monitoring of serum levels of quinidine in patients receiving the drug is recommended.

CPT Codes

80194

Contacts

Last Updated

4/8/2024