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Piperacillin Level

Zosyn, Piperacillin-tazobactam

Test Codes

EPIC: LAB7871, Beaker: XPIP, ARUP: 60842

Department

Send Outs

Specimen Collection Criteria

Collect: One plain Red-top tube.

Physician Office/Draw Specimen Preparation

Centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and freeze (-20°C/-4°F or below).

Preparation for Courier Transport

Transport: 2.0 mL serum, frozen (-20°C/-4°F or below). (Minimum: 1.0 mL)

Rejection Criteria

• Serum Separator (SST) Tubes.
• Specimens not collected and processed as indicated.

In-Lab Processing

Centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and freeze (-20°C/-4°F or below).

Transport: 2.0 mL serum, frozen (-20°C/-4°F or below). (Minimum: 1.0 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 24 hours
Frozen (-20°C/-4°F or below): 7 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Out Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Sunday – Saturday.
Results available in 1-2 days.

Reference Range

By report.

Test Methodology

Quantitative Bioassay.

Interpretation

By report.

Clinical Utility

This test aids in monitoring levels of the antimicrobial drug, piperacillin. Normal peak serum concentration for piperacillin is 389-484 µg/mL with a 4 g IV dose of piperacillin, 209 µg/mL with a 3.375 g IV dose of piperacillin/tazobactam, or 224 µg/mL with a 4.5 g IV dose of piperacillin/tazobactam. Trough serum concentration is not well established.

For bioassay measurements, the presence of other antimicrobial agents may interfere with the assay. Other factors that may influence antimicrobial levels include inherent differences among patients and their underlying physical conditions as well as the dose and route of administration of the antimicrobial agent.

CPT Codes

80299

Contacts

Last Updated

11/3/2023