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Motor and Sensory Neuropathy Evaluation

GM1, Asialo, SGPG, GD1_a, GD1_b, GQ1_b

Test Codes

EPIC: LAB6738, Beaker: XMNSE, ARUP: 2007966

Department

Send Outs

Instructions

This assay includes the following assays: GM1 Antibodies, Asialo-GM1 Abs, MAG Antibodies IgM, SGPG Antibodies IgM, GD1_a Antibodies, GD1_b Antibodies, Neuronal Nuclear Ab, and GQ1_b Antibodies.

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube.
Also acceptable: One plain Red-top tube.

Send specimen for processing immediately after collection.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 2.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL)

Rejection Criteria

• Hemolyzed specimens.
• Lipemic specimens.
• Severely icteric specimens.
• Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells within two hours of collection. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 2.0 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): Unacceptable
Refrigerated (2-8°C or 36-46°F): 14 days
Frozen (-20°C/-4°F or below): 1 year

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Thursday.
Results available in 2-10 days.

Reference Range

By report.

Test Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)/Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot.

Interpretation

Low concentrations of one or more antibodies in this evaluation can be associated with neuropathies secondary to infectious, inflammatory or systemic autoimmune diseases. However, high concentrations of one or more antibodies, especially with paraproteinemia (as indicated by immunofixation electrophoresis (IFE), are suggestive of a primary immune-mediated peripheral neuropathy.

Clinical Utility

This assay aids in the diagnosis and clinical management of patients with motor, sensory or sensorimotor neuropathy associated with aberrant autoantibody responses to antigens in the nervous system. This assay may also be used to evaluate patients with silicone gel implants with neurologic involvement/ neuropathy.

CPT Codes

83516x7, 86255. Add 83516 and/or 86256 if reflexed.

Contacts

Last Updated

10/8/2023