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Jo 1 Antibody, IgG

Jo-1 Antibody, IgG

Test Codes

EPIC: LAB6986, Beaker: JO1A

Department

Special Chemistry

Specimen Collection Criteria

Collect: One Gold-top SST tube. (Minimum Whole Blood: 2.0 mL)

Physician Office/Draw Specimen Preparation

Preparation for Courier Transport

Transport: Centrifuged collection tube, refrigerated (2-8°C or 36-46°F). (Minimum Serum: 0.5 mL)

Rejection Criteria

• Plasma specimens. 
• Severely hemolyzed, lipemic or icteric specimens. 

In-Lab Processing

Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Room temperature is acceptable for a maximum of two hours. (Minimum Serum: 0.5 mL)

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers^® with Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers^® without Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 2 months

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Special Chemistry Laboratory

Performed

Monday – Friday.
Results available within 2 business days.

Reference Range

Negative:  < 1.0 U
Equivocal:  NA
Positive:  ≥ 1.0 U

Test Methodology

Multiplex Flow Assay.

Interpretation

Jo-1 antibodies are found in patients with polymyositis, dermatomyositis, myositis associated with another rheumatic disease, or with interstitial lung disease.

Clinical Utility

Antibodies to the autoantigen Jo-1 (hystidyl-RNA synthetase) are found in a subgroup of connective tissue disease patients with pure polymyositis, pure dermatomyositis or myositis associated with another rheumatic disease. Antibodies to Jo-1 are found in 18-36% of all patients satisfying the criteria for myositis. This antibody is more common in polymyositis than dermatomyositis and is rarely found in other disease states. Antibodies to Jo-1 have also been associated with interstitial lung disease.

CPT Codes

86235
LOINC: 44332-5

Contacts

Last Updated

2/10/2024