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Glutamic Acid Decarboxylase (GAD65) Antibody

GAD Antibody, GAD65, stiff-man syndrome

Test Codes

EPIC: LAB6040, Beaker: XGAD, Mayo: GAD65S

Department

Send Outs

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Gold-top SST tube.

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.5 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL)

Rejection Criteria

• Grossly hemolyzed specimens.
• Grossly icteric specimens.
• Grossly lipemic specimens.
• Specimens not collected and processed as indicated.

In-Lab Processing

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Transfer serum to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.5 mL serum, refrigerated (2-8°C or 36-46°F). (Minimum: 1.0 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 28 days
Frozen (-20°C/-4°F or below): 28 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Medical Laboratories, Rochester, MN.

Performed

Sunday – Saturday.
Results available in 3-7 days.

Reference Range

By report.

Test Methodology

Radioimmunoassay (RIA).

Interpretation

This test was developed and it's performance characteristics determined by the department of Laboratory Medicine and Pathology, Mayo Clinic Rochester. It has not been cleared or approved by the U.S. Food and Drug Administration.

Clinical Utility

This assay aids in assessing susceptibility to autoimmune (type 1, insulin-dependent) diabetes mellitus and related endocrine disorders (e.g., thyroiditis and pernicious anemia), distinguishing between patients with type 1 and type 2 diabetes, and confirming a diagnosis of stiff-man syndrome and related newly recognized autoimmune encephalomyelopathies.

CPT Codes

86341
LOINC:  20642-5, 30059-0, 22652-2, 53708-4

Contacts

Last Updated

10/2/2023