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Disopyramide Level

Norpace®, Napamide®, Rythmodan

Test Codes

ARUP #2011632, Order as a Miscellaneous Send Out.

Specimen Collection Criteria

Collect (preferred specimen): One plain Red-top tube.
Also acceptable: One Lavender-top EDTA tube.

Do not use Serum Separator Tubes.
Time of Collection: Trough, just prior to the next dose.

Physician Office/Draw Specimen Preparation

Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Preparation for Courier Transport

Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Rejection Criteria

Serum Separator (SST) tubes.

Specimens not collected and processed as indicated.

In-Lab Processing

Centrifuge to separate serum or plasma from cells within two hours of collection. Transfer serum or plasma to a plastic transport tube and refrigerate (2-8°C or 36-46°F).

Transport: 1.0 mL serum or plasma, refrigerated (2-8°C or 36-46°F). (Minimum: 0.5 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 4 days
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 2 months

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Tuesday, Friday.
Results available in 2-6 days.

Reference Range

Therapeutic: 2.0-6.0 mcg/mL.
Toxic: Greater than 6.0 mcg/mL.

Test Methodology

Quantitative Enzyme Multiplied Immunoassay Technique.

Interpretation

Disopyramide exhibits nonlinear protein binding within the therapeutic range. Unbound Disopyramide increases disproportionatly to increases in Disopyramide dosing.

Clinical Utility

Disopyramide is used in the treatment of unifocal premature (ectopic) ventricular contractions and ventricular tachycardia. This assay is used for the therapeutic monitoring and toxicity assessment of disopyramide.

CPT Codes

80299

Contacts

Last Updated

5/27/2021