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D Lactate, Urine

D-Lactate, Urine

Test Codes

EPIC: LAB6250, Beaker: XLACU, Mayo: DLAU

Department

Send Outs

Instructions

Please refer to the Specimen Collection Manual for instructions on 24-Hour Urine Collection:

• Urine 24-Hour Collection - Inpatient
• Urine 24-Hour Collection - Outpatient
• Urine 24-Hour Collection - Outreach

Specimen Collection Criteria

Collect (preferred specimen): 24-hour urine sample with no preservative.
Also acceptable: 0.50 mL of random urine specimen in a screw-capped container (preferred) or other sterile collection cup. (Minimum: 0.15 mL)

• Keep 24-hour urine specimen iced or refrigerated during collection.
• Include start and end dates and times for the collection period on the specimen container.

Urine Preservative Options
No Preservative	6N Hydrochloric Acid	Boric Acid (10g)	Sodium Carbonate	50% Acetic Acid
REQUIRED	Unacceptable	Unacceptable	Unacceptable	Unacceptable

Physician Office/Draw Specimen Preparation

Maintain specimens refrigerated (2-8°C or 36-46°F) prior to transport.

Preparation for Courier Transport

Transport: Entire 24-hour urine collection, or random urine, refrigerated (2-8°C or 36-46°F).

Rejection Criteria

Specimens not collected and processed as indicated.

In-Lab Processing

Measure total volume of 24-hour urine specimen. Record total volume and collection start and end dates and times in the LIS system. Aliquot 0.50 mL from the well-mixed 24-hour urine collection or random urine into a plastic transport tube and freeze. (Minimum: 0.15 mL)

Storage

Specimen Stability for Testing:

Room Temperature (20-26°C or 68-78.8°F): 90 days
Refrigerated (2-8°C or 36-46°F): 90 days
Frozen (-20°C/-4°F or below): 90 days

Specimen Storage in Department Prior to Disposal:

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to Mayo Medical Laboratories, Rochester, MN.

Performed

Monday, Thursday.
Results available in 3-6 days.

Reference Range

See report.

Test Methodology

Gas Chromatography- Mass Spectrometry (GCMS) Stable Isotope Dilution Analysis.

Interpretation

D-lactate is a product of bacterial overgrowth in the gastrointestinal tract. It should not be confused with L-lactate which accumulates in some metabolic acidosis.

D-lactate is readily cleared. Urine is the preferred sample.

Elevated levels of D-lactate are often seen in patients with the short-bowel syndrome and following jejunoileal bypass.

Clinical Utility

This assay is used to investigate D-lactate acidosis. D-lactate acidosis has been described in patients with jejunoileal bypass and short-bowel syndrome.

CPT Codes

83605

Contacts

Last Updated

2/10/2024