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CYP2C19 Genotyping

CYP2C19 Genotyping for Clopidogrel/Plavix, Clopidogrel (Plavix), Cytochrome P450 2C19 Genotyping, Plavix (Clopidogrel), Treatment Resistant Depression Panel, Plavix Inhibition

Test Codes

EPIC: LAB7036, Beaker: XYP19, ARUP: 3001508

Department

Send Outs

Specimen Collection Criteria

Collect: One Lavender-top EDTA tube. (Minimum: 1.0 mL)
Also acceptable: One Yellow-top ACD tube. 

Physician Office/Draw Specimen Preparation

Do not centrifuge. Maintain whole blood refrigerated (2-8°C or 36-46°F) prior to transport.

Preparation for Courier Transport

Transport: Whole blood refrigerated (2-8°C or 36-46°F). Minimum: 1.0 mL)

Rejection Criteria

Specimens not collected and processed as indicated.

This test will only be performed once in a lifetime for a patient.

Storage

Specimen Stability for Testing:

Whole Blood
Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 1 week
Frozen (-20°C/-4°F or below): 1 month


Specimen Storage in Department Prior to Disposal:

Extracted DNA may be available for additional testing if clinically indicated.

Specimen retention time is determined by the policy of the reference laboratory. Contact the Send Outs Laboratory with any questions.

Laboratory

Sent to ARUP Laboratories, Salt Lake City, UT.

Performed

Varies.
Results available in 6-11 business days.

Reference Range

By Report.

Test Methodology

Polymerase Chain Reaction (PCR)/ Fluorescence.

Interpretation

This test detects by report (normal) allele CYP2C19*1, and the following mutant alleles: *2 → *10, *13, and *17.

Clinical Utility

• Based on the CYP2C19 genotype, patients may be classified as extensive, intermediate, poor, or ultrarapid metabolizers of Clopidogrel. Drug dose selection based on genotype is the basis of individualized therapy.
• Testing is recommended on patients to be started on Plavix (Clopidogrel) therapy.

CPT Codes

81225
LOINC:  31208-2, 57132-3, 50398-7

Contacts

Last Updated

10/3/2023