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Bone Alkaline Phosphatase, Serum

Bone Specific Alkaline Phosphatase, BAP

Test Codes

EPIC: LAB6846, SOFT: BAP

Department

Special Chemistry

Specimen Collection Criteria

Collect (preferred specimen): One Gold-top SST tube. (Minimum Whole Blood: 2.0 mL)
Also acceptable: One plain Red-top tube. (Minimum Whole Blood: 2.0 mL)

Physician Office/Draw Specimen Preparation

Let specimen clot 30-60 minutes then centrifuge to separate serum from cells. Refrigerate (2-8°C or 36-46°F) the centrifuged collection tube prior to transport. (Minimum Whole Blood: 2.0 mL)

Preparation for Courier Transport

Transport: Centrifuged collection tube, refrigerated (2-8°C or 36-46°F). (Minimum Serum: 0.5 mL).

Rejection Criteria

Plasma Specimens. 

Severely hemolyzed, lipemic or icteric specimens. 

In-Lab Processing

Let specimen clot 30-60 minutes then immediately centrifuge to separate serum from cells. Room temperature is acceptable for a maximum of two hours. (Minimum Serum: 0.5 mL)

Storage

Specimen Stability for Testing:

Centrifuged SST Tubes and Microtainers^® with Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): Unacceptable

Red-top Tubes and Microtainers^® without Separator Gels
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): Unacceptable
Frozen (-20°C/-4°F or below): Unacceptable

Serum Specimens (Pour-Overs)
Room Temperature (20-26°C or 68-78.8°F): 2 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 60 days

Specimen Storage in Department Prior to Disposal:

Refrigerated (2-8°C or 36-46°F): 7 days

Laboratory

Royal Oak Special Testing Laboratory

Performed

Tuesday, Friday.
Results available within 3 business days.

Reference Range

Age	Male (mcg/L)	Female (mcg/L)
6 Months - 2 Years	27.7-114.1	29.5-135.6
3-6 Years	27.5-95.9	29.0-100.8
7-9 Years	43.9-131.0	32.2-149.0
10-12 Years	44.1-145.3	39.7-152.7
13-15 Years	24.1-197.9	11.8-127.0
16-17 Years	12.3-118.1	7.7-40.3
18-24 Years	7.3-25.1
25 Years or Older	3.9-16.8
≥ 18 Years, Premenopausal		2.0-13.8
≥ 18 Years, Postmenopausal		4.4-19.0

Test Methodology

Chemiluminescent Enzyme Immunoassay.

Clinical Utility

This assay aids in the diagnosis of metabolic bone diseases including Paget disease, osteomalacia, and other states of high bone turnover. The assay is also useful for monitoring the efficacy of antiresorptive therapies including post-menopausal osteoporosis treatment.

This assay is not a screening test for osteoporosis. Diagnosis of osteoporosis should be made on the basis of bone density.

Liver-derived Alkaline Phosphatase (ALP) has cross-reactivity in this assay: approximately 100 U/L of liver ALP gives a result of 2.5-5.8 mcg/L. Therefore, specimens with significant elevations of liver ALP activity may yield elevated bone ALP results.

CPT Codes

84080, 17838-4
LOINC:  6768-6,1777-2

Contacts

Last Updated

1/4/2023