Benzodiazepine Confirmation, Urine
Valium, Librium, Xanax, Ativan, Tranxene, Serax, Halcion
Test Codes
EPIC: LAB6918, BNZCF
Department
Toxicology
Specimen Collection Criteria
Collect: 50 mL random urine in a screw-capped container (preferred) or other sterile collection cup with no preservative. (Minimum: 30 mL)
- Refrigerate the specimen immediately after collection.
- Record the exact time of specimen collection on the container or in the computer system.
Physician Office/Draw Specimen Preparation
Maintain specimen refrigerated (2-8°C or 36-46°F) prior to transport.
Preparation for Courier Transport
Transport: 50 mL urine, refrigerated (2-8°C or 36-46°F). (Minimum: 30 mL)
Rejection Criteria
- Specimens not collected and processed as indicated.
- Urine Vacutainer® tubes. Urine received in a glass or plastic tube with a rubber stopper may contain insufficient sample volume, preclude confirmatory testing, and give rise to contaminants and artifacts.
In-Lab Processing
Analyze specimen immediately upon receipt in the Laboratory.
Storage
Specimen Stability for Testing:
Room Temperature (20-26°C or 68-78.8°F): 72 hours
Refrigerated (2-8°C or 36-46°F): 7 days
Frozen (-20°C/-4°F or below): 3 months
Specimen Storage in Department Prior to Disposal:
Refrigerated (2-8°C or 36-46°F): 7 days
Laboratory
Canton Main Laboratory
Dearborn Toxicology Laboratory
Farmington Hills Toxicology Laboratory
Grosse Pointe Toxicology Laboratory
Lenox Main Laboratory
Livonia Main Laboratory
Royal Oak Toxicology Laboratory
Troy Toxicology Laboratory
Taylor Toxicology Laboratory
Trenton Toxicology Laboratory
Wayne Toxicology Laboratory
NOTE: Screens are performed at Canton,
Dearborn, Farmington Hills, Grosse Pointe, Royal Oak, Taylor, Trenton, Troy and
Wayne. All confirmations are performed at Royal Oak Toxicology
Laboratory.
Performed
Results available within 3-5 business days of receipt .
Reference Range
Negative.
Positive cutoff: 200 ng/mL.
Test Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS).
Note: Confirmation performed at Royal Oak only.
The confirmation component of this test was developed by Beaumont Health. It has not been cleared or approved by the FDA. The laboratory is regulated under CLIA as qualified to perform high-complexity testing. This test is used for clinical purposes and should not be regarded as investigational or for research.
Interpretation
Drugs identified: Clonazepam, Diazepam, Oxazepam, Temazepam, Nordiazepam, Chlordiazepoxide, Midazolam, Alprazolam, Clobazam, Estazolam, Lorazepam, Alphahydroxytriazolam, Flurazepam, Flunitrazepam.
Clinical Utility
This assay is used to aid in the diagnosis and treatment of benzodiazepine use or abuse. This assay provides a preliminary analytical result. Positive results are confirmed by chromatographic methods. Benzodiazepines are central nervous system depressants composed of over 20 compounds. They are used clinically as sedatives, hypnotics, anxiolytics, muscle relaxants, antiepileptics, and in the treatment of alcohol withdrawal. Benzodiazepines are extensively metabolized with half-lives ranging from 1 to 100 hours. Urine levels vary due to each patient's metabolic and excretion rates.
CPT Codes
80347
LOINC: 70142-5, 46976-7
Contacts
Toxicology Laboratory – RO
248-551-8058
Name: Toxicology Laboratory – RO
Location:
Phone: 248-551-8058
Chemistry Laboratory – DBN
313-436-2196
Name: Chemistry Laboratory – DBN
Location:
Phone: 313-436-2196
Chemistry Laboratory – FH
947-521-5252
Name: Chemistry Laboratory – FH
Location:
Phone: 947-521-5252
Chemistry Laboratory – GP
313-473-1807
Name: Chemistry Laboratory – GP
Location:
Phone: 313-473-1807
Chemistry Laboratory – TR
248-964-8070
Name: Chemistry Laboratory – TR
Location:
Phone: 248-964-8070
Chemistry Laboratory – TYL
313-295-5360
Name: Chemistry Laboratory – TYL
Location:
Phone: 313-295-5360
Chemistry Laboratory – TRN
734-671-3165
Name: Chemistry Laboratory – TRN
Location:
Phone: 734-671-3165
Laboratory – CTN
734-454-8024
Name: Laboratory – CTN
Location:
Phone: 734-454-8024
Lenox Laboratory – LNX
947-523-4070
Name: Lenox Laboratory – LNX
Location:
Phone: 947-523-4070
Livonia Laboratory – LVA
947-523-4370
Name: Livonia Laboratory – LVA
Location:
Phone: 947-523-4370
Main Laboratory –WYN
734-467-4274
Name: Main Laboratory –WYN
Location:
Phone: 734-467-4274
Last Updated
8/30/2023
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